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Does simvastatin cause more myotoxicity compared with other statins?
At the same time in increased my fiber significantly (metemucil and high fiber cereal daily) and began taking one 1000mg of fish oil each day.
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These reported symptoms are generally not serious and reversible upon statin discontinuation, with variable times to symptom onset (1 day to years) and symptom resolution (median of 3 weeks).
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In addition, Simvastatin significantly decreased the proportion of patients with new lesions and with new total occlusions.
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Pedersen TR, Kjekshus J, Berg K, Haghfelt T, Faergeman O, Thorgeirsson G, Pyorala K, Miettinen T, Wilhelmsen L, Olsson AG, Wedel "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S).
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Evidence from large-scale, randomized studies shows that statin therapy reduces the incidence of heart attacks, strokes, and revascularization procedures by about one fifth for each reduction of 40 mg per deciliter (1 mmol per liter) in the low-density lipoprotein (LDL) cholesterol level.
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An additional study in boys aged 8-14 that used 650 mg each of EPA and DHA for 16 weeks found improvements in the Attention Problems subset of the Child Behavior Checklist (CBCL) for children with ADHD (with improvements being seen in the overall CBCL score for children both with and without ADHD).
Antiretrovirals may also cause lipids to rise, thus creating both the need for lipid therapy and the setting in which it is more toxic.
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Both drugs have a low but serious risk of liver damage, and simvastatin carries an additional risk of muscle inflammation in some patients.
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There is no preferred medication for this condition as response to any given medication differs from person to person.
Although only based on one study, in men with central obesity and a wide variety of general health complaints supplementation has outright abolished all measured complaints such as loss of libido, high appetite, pain, and forgetfulness.
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An enzyme called CYP3A4 helps break down lovastatin (generic, Mevacor, Altoprev).
One meta-analysis has claimed insufficient evidence to support an effect of fish oil (using mostly underpowered studies) and a more robust trial of 2399 women has failed to find a protective effect with 800mg DHA supplementation (1.
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In other instances, the liver disease ultimately resolved with stopping atorvastatin.
Statin drugs like simvastatin (sold as Zocor) and atorvastatin (Lipitor) lower blood levels of LDL, the so-called bad cholesterol, thereby slowing the buildup of plaque in the arteries.
A lot of people choose generics because a lot of money is spent by the manufacturers of brand-name drugs to advertise their products.
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Egan: The safety labeling changes were required under the FDA Amendments Act (FDAAA).
Yet, with so many people on statins to treat or prevent heart disease and stroke, it would seem that much more attention should be paid to the grapefruit and pomegranate fruit interaction with statins.
The health information contained herein is provided for general educational purposes only.
You should know Answers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor.
Also, the participants in our study had moderate-to-severe airway obstruction, and it is unclear whether our observation that simvastatin was not beneficial would apply to patients with less impairment.
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